The role of dendritic cells in cancer and anti-tumor immunity.

TitleThe role of dendritic cells in cancer and anti-tumor immunity.
Publication TypeJournal Article
Year of Publication2021
AuthorsMarciscano AE, Anandasabapathy N
JournalSemin Immunol
Date Published2021 Feb

Dendritic cells (DC) are key sentinels of the host immune response with an important role in linking innate and adaptive immunity and maintaining tolerance. There is increasing recognition that DC are critical determinants of initiating and sustaining effective T-cell-mediated anti-tumor immune responses. Recent progress in immuno-oncology has led to the evolving insight that the presence and function of DC within the tumor microenvironment (TME) may dictate efficacy of cancer immunotherapies as well as conventional cancer therapies, including immune checkpoint blockade, radiotherapy and chemotherapy. As such, improved understanding of dendritic cell immunobiology specifically focusing on their role in T-cell priming, migration into tissues and TME, and the coordinated in vivo responses of functionally specialized DC subsets will facilitate a better mechanistic understanding of how tumor-immune surveillance can be leveraged to improve patient outcomes and to develop novel DC-targeted therapeutic approaches.

Alternate JournalSemin Immunol
PubMed ID34023170
PubMed Central IDPMC8545750
Grant ListR01 AR070234 / AR / NIAMS NIH HHS / United States